[29] Ultraviolet A radiation-induced apoptosis

摘要: Publisher Summary Ultraviolet (UV) radiation has been used for decades in the treatment of patients with a variety T-cell-mediated skin diseases, including atopic dermatitis and psoriasis. Among different phototherapeutic modalities currently available, recent interest focused on use irradiation devices that allow exposure human to wavelengths longer UVA range, i.e., UVA-1 (340-400 nm). The almost complete absence erythemogenic shorter than 340 nm allows single doses up 130 J/cm2. These clinical developments have stimulated studies mechanisms by which phototherapy works. From these it learned improves symptoms diseases killing skin-infiltrating T cells through initiation apoptosis. made possible unique combination vivo methods monitoring apoptosis situ undergoing vitro techniques mimic therapeutic situation as closely helped greatly unraveling photobiological molecular induces T-cell This chapter describes discusses their relevance radiation-induced