Proteins: Coexistence of Stability and Flexibility

作者: Shlomi Reuveni , Rony Granek , Joseph Klafter

DOI: 10.1103/PHYSREVLETT.100.208101

关键词: GeneralizationStatistical physicsStability (probability)Equation of stateFractal dimensionProtein Data BankMathematicsTopology (chemistry)Protein foldingFractal

摘要: We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and a generalization Landau-Peierls instability criterion fractals. The relates fractal dimension df, spectral ds, number amino acids N. Deviations may render unfolded. nature proteins is shown to bridge their seemingly conflicting properties stability flexibility. Over 500 have been analyzed (df, N) found obey this state.

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