TRICOM Poxviral-Based Vaccines for the Treatment of Cancer

作者: Caroline Jochems , Jeffrey Schlom , James L. Gulley

DOI: 10.1007/978-3-7091-1818-4_10

关键词: Clinical trialImmune systemCancer researchTumor cellsChemotherapyCancerAntigenCostimulatory MoleculeImmune checkpoint inhibitorsMedicine

摘要: TRICOM poxviral-based vaccines are novel “off-the-shelf” agents designed to generate a robust immune response against tumor-associated antigens, which commonly expressed on tumor cells. In this chapter, we elucidate the science behind development and use of these vaccines. We also highlight results preclinical clinical trials potential benefits combining them with standard-of-care chemotherapy other immunotherapies.

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