Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings.

摘要: Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over mean time 7.4 years. The age at onset was low (56.2 years). At onset, eight had visuo-spatial memory impairment. A minority showed early signs occipital lobe involvement visual agnosia or hemianopia. Eight developed dementia after course five 18F-FDG-PET data six analysed statistical parametric mapping. They hypometabolism centred on the lateral medial parietal associative cortex, variable adjacent temporal cortex. frontal lobes, possibly related to deafferenting areas control eye movements. Atrophy markedly asymmetric in subset cases. Autopsy performed one patient. Presenile location, asymmetry suggest that PCA represents biologically separable variant Alzheimer's disease.