The Effect of Brain Atrophy on Cerebral Hypometabolism in the Visual Variant of Alzheimer Disease

摘要: Background Brain glucose metabolic rates measured by positron emission tomography can be more affected partial volume effects in Alzheimer disease (AD) than healthy aging because of disease-associated brain atrophy. Objective To determine whether the distinct distribution cerebral lesions patients with visual variant AD (AD + VS) represents a true index neuronal/synaptic dysfunction or is consequence Setting Government research hospital. Design Resting rate for was cross-sectional study and VS groups control subjects. Segmented magnetic resonance images were used to correct Patients had prominent visuospatial symptoms. There 15 AD, 10 VS, 37 age-matched Main Outcome Measure Measurement metabolism. Results Before atrophy correction, group, compared subjects, showed hypometabolism primary extrastriate areas parietal superior temporal cortical areas. Compared group association After remained significantly different between controls 2 groups. Conclusions The reductions represent loss functional activity are not simply an artifact caused patterns indicate differential development