The gasotransmitter hydrogen sulfide in hemodialysis patients.
作者： Ingrosso D , Sepe I , De Santo Ng , Lanza D , Capasso R
DOI:
关键词: Pharmacology 、 Hydrogen sulfide 、 Medicine 、 Hemodialysis 、 Sulfurtransferase 、 Nitric oxide 、 Cystathionine beta synthase 、 Blood pressure 、 Chronic hemodialysis 、 Endogeny
摘要: Hydrogen sulfide, H2S, is the third endogenous gas with cardiovascular properties (the others are nitric oxide and carbon monoxide). In fact, among other important signaling functions, H2S plays a key role in regulating blood pressure. Cystathionine s-synthase, cystathionine γ-lyase (CSE) 3-mercaptopyruvate sulfurtransferase principal enzymes devoted to formation. We have recently shown that levels decreased patients on chronic hemodialysis through transcriptional deregulation of CSE gene, hinting at possibility link exists between this finding hypertension high mortality typical these patients.
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