Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide
作者： H. Kimura , N. Shibuya , Y. Mikami , Y. Kimura , N. Nagahara
DOI: 10.1093/JB/MVP111
关键词:
摘要: Hydrogen sulfide (H(2)S) has been recognized as a smooth muscle relaxant. Cystathionine gamma-lyase, which is localized to muscle, thought be the major H(2)S-producing enzyme in thoracic aorta. Here we show that 3-mercaptopyruvate sulfurtransferase (3MST) and cysteine aminotransferase (CAT) are vascular endothelium aorta produce H(2)S. Both 3MST CAT were endothelium. Lysates of endothelial cells produced H(2)S from alpha-ketoglutarate. The present study provides new insight into production release relaxant
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Watanabe K, Umemura S, Ubuka T, Yuasa S, Kinuta M, Purification and characterization of mitochondrial cysteine aminotransferase from rat liver. Physiological chemistry and physics. ,vol. 10, pp. 483- 500 ,(1978)
Reiko Akagi, Purification and characterization of cysteine aminotransferase from rat liver cytosol. Acta Medica Okayama. ,vol. 36, pp. 187- 197 ,(1982) , 10.18926/AMO/30697
Wei Yang, Guangdong Yang, Xuming Jia, Lingyun Wu, Rui Wang, Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms. The Journal of Physiology. ,vol. 569, pp. 519- 531 ,(2005) , 10.1113/JPHYSIOL.2005.097642
Weimin Zhao, Jing Zhang, Yanjie Lu, Rui Wang, The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener The EMBO Journal. ,vol. 20, pp. 6008- 6016 ,(2001) , 10.1093/EMBOJ/20.21.6008
Yasushi Enokido, Eri Suzuki, Kazu Iwasawa, Kazuhiko Namekata, Hitoshi Okazawa, Hideo Kimura, Cystathionine β-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS The FASEB Journal. ,vol. 19, pp. 1854- 1856 ,(2005) , 10.1096/FJ.05-3724FJE
Noriyuki Nagahara, Takeshi Nishino, Role of Amino Acid Residues in the Active Site of Rat Liver Mercaptopyruvate Sulfurtransferase Journal of Biological Chemistry. ,vol. 271, pp. 27395- 27401 ,(1996) , 10.1074/JBC.271.44.27395
G. Yang, L. Wu, B. Jiang, W. Yang, J. Qi, K. Cao, Q. Meng, A. K. Mustafa, W. Mu, S. Zhang, S. H. Snyder, R. Wang, H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase Science. ,vol. 322, pp. 587- 590 ,(2008) , 10.1126/SCIENCE.1162667
Norihiro Shibuya, Makiko Tanaka, Mikiharu Yoshida, Yuki Ogasawara, Tadayasu Togawa, Kazuyuki Ishii, Hideo Kimura, 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxidants & Redox Signaling. ,vol. 11, pp. 703- 714 ,(2009) , 10.1089/ARS.2008.2253
B Teague, S Asiedu, P K Moore, The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility British Journal of Pharmacology. ,vol. 137, pp. 139- 145 ,(2002) , 10.1038/SJ.BJP.0704858
Isao ISHII, Noriyuki AKAHOSHI, Xiao-Nian YU, Yuriko KOBAYASHI, Kazuhiko NAMEKATA, Gen KOMAKI, Hideo KIMURA, Murine cystathionine γ-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression Biochemical Journal. ,vol. 381, pp. 113- 123 ,(2004) , 10.1042/BJ20040243