作者: P. Boksa
DOI: 10.1007/978-1-4612-4672-5_62
关键词: Splanchnic nerves 、 Chromaffin cell 、 Catecholamine 、 Internal medicine 、 Adrenal medulla 、 Chemistry 、 Substance P 、 Endocrinology 、 Stimulation 、 Tyrosine hydroxylase 、 Secretion
摘要: The classical view of secretion from the adrenal medulla was that a relatively simple system. Since early 1930s it has been known release acetylchol ine (ACh) stimulated splanchnic nerve causes catecholamines, adrenaline and noradrenaline, chromaffin cells [1]. In addition to these acute effects on catecholamine release, long-term stimulation with ACh (in time course hours nays) later found produce other biochemical changes in cell. A well-studied example this is ability for induce synthesis tyrosine hydroxylase (TOH, EC 1.14.16.2), rate-limiting enzyme [2]. Thus can two types responses cells. These differ their courses (one one long-term) also ionic dependences (ACh-stimulated strictly Ca 2t-dependent [3], while ACh-stimulated induction TOH not [4]).