Substance P Effects on the Long-Term Regulation of Adrenal Catecholamine Levels

作者: P. Boksa

DOI: 10.1007/978-1-4612-4672-5_62

关键词: Splanchnic nervesChromaffin cellCatecholamineInternal medicineAdrenal medullaChemistrySubstance PEndocrinologyStimulationTyrosine hydroxylaseSecretion

摘要: The classical view of secretion from the adrenal medulla was that a relatively simple system. Since early 1930s it has been known release acetylchol ine (ACh) stimulated splanchnic nerve causes catecholamines, adrenaline and noradrenaline, chromaffin cells [1]. In addition to these acute effects on catecholamine release, long-term stimulation with ACh (in time course hours nays) later found produce other biochemical changes in cell. A well-studied example this is ability for induce synthesis tyrosine hydroxylase (TOH, EC 1.14.16.2), rate-limiting enzyme [2]. Thus can two types responses cells. These differ their courses (one one long-term) also ionic dependences (ACh-stimulated strictly Ca 2t-dependent [3], while ACh-stimulated induction TOH not [4]).

参考文章(17)
W. W. Douglas, R. P. Rubin, The role of calcium in the secretory response of the adrenal medulla to acetylcholine The Journal of Physiology. ,vol. 159, pp. 40- 57 ,(1961) , 10.1113/JPHYSIOL.1961.SP006791
Hans Thoenen, Trans-synaptic enzyme induction Life Sciences. ,vol. 14, pp. 223- 235 ,(1974) , 10.1016/0024-3205(74)90052-6
D E Clapham, E Neher, Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. The Journal of Physiology. ,vol. 347, pp. 255- 277 ,(1984) , 10.1113/JPHYSIOL.1984.SP015065
W. Feldberg, B. Minz, H. Tsudzimura, The mechanism of the nervous discharge of adrenaline The Journal of Physiology. ,vol. 81, pp. 286- 304 ,(1934) , 10.1113/JPHYSIOL.1934.SP003136
Maryka Quik, Theodore L. Sourkes, Regulation of adrenal tyrosine hydroxylase activity: Neuronal versus local control studied with apomorphine☆ Biochemical Pharmacology. ,vol. 25, pp. 1157- 1166 ,(1976) , 10.1016/0006-2952(76)90363-4
J. Kessler, J. Adler, I. Black, Substance P and somatostatin regulate sympathetic noradrenergic function. Science. ,vol. 221, pp. 1059- 1061 ,(1983) , 10.1126/SCIENCE.6192502