Acquired factor VIII deficiency after consuming the dried gallbladder of a cobra, Naja naja

摘要: Acquired factor VIII deficiency is very rare, often fatal. It associated with pregnancy, autoimmune diseases, malignancy, and drugs, although no underlying cause found in 50%. A 49-year-old male was referred right shoulder bruising. The coagulation test showed a prolonged activated partial thromboplastin time. level less than 1%, the inhibitor antibody titer 246 Bethesda units/mL. findings were compatible acquired deficiency. He had consumed dried gallbladder of cobra, Naja naja, for two weeks, it contained venom. After initial treatment VIII, he did not take supplemental VIII. patient readmitted left forearm swelling. lost consciousness suddenly brain computed tomography (CT) revealed subdural hematoma. Despite administering recombinant VII, his bleeding controlled died.