The Effects of Different Types of Antimicrobial Agents on Plasma Endotoxin Activity in Gram-Negative Bacterial Infection

摘要: There is hardly any doubt that endotoxin (lipopolysaccharide) one of the main factors cause release cytokines and thus induce sepsis syndrome subsequent organ failure in serious Gram-negative infections. Most endotoxic activities are mediated through lipid part lipopolysaccharide molecule, A. In clinical studies, plasma levels septic patients have been found to be related outcome [1,6, 12]. vitro animal experiments studies shown antibiotic therapy, which absolutely necessary treatment a bacterial infection, induces an increased lipopolysaccharides infections [2-4, 10, 11, 13-16, 19, 24, 29, 30-33, 35]. The toxic principle lipopolysaccharide, A, normally sequestered wall bacteria, exposed by action.