Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer
作者： TOSHIHIRO NAKAO , TAKASHI IWATA , MASANORI HOTCHI , KOZO YOSHIKAWA , JUN HIGASHIJIMA
DOI: 10.3892/OR.2015.4196
关键词: Microarray 、 Biomarker (medicine) 、 Tegafur 、 Cancer 、 Medicine 、 Standard treatment 、 Chemoradiotherapy 、 Internal medicine 、 Oncology 、 Preoperative care 、 Colorectal cancer
摘要: Preoperative chemoradiotherapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer. However, no specific biomarker been identified to predict a response preoperative CRT. The aim of present study was assess gene expression patterns cancer their responses Fifty-nine were subjected Patients randomly assigned receive CRT tegafur/gimeracil/oteracil (S-1 group, n=30) or tegafur-uracil (UFT n=29). Gene changes studied cDNA and miRNA microarray. association between evaluated. microarray showed that 184 genes significantly differentially expressed responders non‑responders in S-1 group. Comparatively, 193 UFT TBX18 upregulation common both groups whereas BTNL8, LOC375010, ADH1B, HRASLS2, LOC284232, GCNT3 ALDH1A2 lower when compared non-responders. Using microarray, we found 7 16 non-responders groups, respectively. miR-223 higher group tended be several likely useful establishing individualized therapies
spandidos.org参考文章(20)
Il-Jin Kim, Seok-Byung Lim, Hio Chung Kang, Hee Jin Chang, Sun-A Ahn, Hye-Won Park, Sang-Geun Jang, Jae-Hyun Park, Dae Yong Kim, Kyung Hae Jung, Hyo Seong Choi, Seung-Yong Jeong, Dae Kyung Sohn, Duck-Woo Kim, Jae-Gahb Park, Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer Diseases of The Colon & Rectum. ,vol. 50, pp. 1342- 1353 ,(2007) , 10.1007/S10350-007-277-7
Masanori Hotchi, Hiroshi Okitsu, Murato Miura, Madoka Hamada, Yasuhide Sonaka, Yoh Fukuda, Tsutomu Ando, Shinji Kuratate, A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer Journal of Cancer Therapy. ,vol. 03, pp. 989- 995 ,(2012) , 10.4236/JCT.2012.326127
Eun Mi Lee, Yong Sang Hong, Kyu-pyo Kim, Jae-Lyun Lee, Sun Young Kim, Young Suk Park, Doo Ho Choi, Jong Hoon Kim, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim, Ju Hee Lee, Ah Young Kim, Tae Won Kim, Phase II study of preoperative chemoradiation with S-1 plus oxaliplatin in patients with locally advanced rectal cancer. Cancer Science. ,vol. 104, pp. 111- 115 ,(2013) , 10.1111/CAS.12041
Eva Maria Pinatel, Francesca Orso, Elisa Penna, Daniela Cimino, Angela Rita Elia, Paola Circosta, Patrizia Dentelli, Maria Felice Brizzi, Paolo Provero, Daniela Taverna, miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions PLoS ONE. ,vol. 9, pp. e84859- ,(2014) , 10.1371/JOURNAL.PONE.0084859
Masanori Hotchi, microRNA expression is able to predict response to chemoradiotherapy in rectal cancer. Molecular and Clinical Oncology. ,vol. 1, pp. 137- 142 ,(2012) , 10.3892/MCO.2012.9
Shinya Morimoto, Mitsuo Shimada, Nobuhiro Kurita, Hirohiko Sato, Takashi Iwata, Masanori Nishioka, Kozo Yoshikawa, Tomohiko Miyatani, Hideya Kashihara, Chie Takasu, Hitoshi Ikushima, Preoperative radiotherapy combined with S-1 for advanced lower rectal cancer: phase I trial. Hepato-gastroenterology. ,vol. 59, pp. 1428- 1432 ,(2011) , 10.5754/HGE11699
Liping Liang, Ji Zhu, Nicholas G. Zaorsky, Yun Deng, Xingzhong Wu, Yong Liu, Fangqi Liu, Guoxiang Cai, Weilie Gu, Lijun Shen, Zhen Zhang, MicroRNA-223 enhances radiation sensitivity of U87MG cells in vitro and in vivo by targeting ataxia telangiectasia mutated. International Journal of Radiation Oncology Biology Physics. ,vol. 88, pp. 955- 960 ,(2014) , 10.1016/J.IJROBP.2013.12.036
Toshiaki Watanabe, Takashi Kobunai, Takashi Akiyoshi, Keiji Matsuda, Soichiro Ishihara, Keijiro Nozawa, Prediction of response to preoperative chemoradiotherapy in rectal cancer by using reverse transcriptase polymerase chain reaction analysis of four genes Diseases of The Colon & Rectum. ,vol. 57, pp. 23- 31 ,(2014) , 10.1097/01.DCR.0000437688.33795.9D
J Kurashige, M Watanabe, M Iwatsuki, K Kinoshita, S Saito, Y Hiyoshi, H Kamohara, Y Baba, K Mimori, H Baba, Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma British Journal of Cancer. ,vol. 106, pp. 182- 188 ,(2012) , 10.1038/BJC.2011.509
Susumu Saigusa, Yuji Toiyama, Koji Tanaka, Takeshi Yokoe, Yoshinaga Okugawa, Aya Kawamoto, Hiromi Yasuda, Yasuhiro Inoue, Chikao Miki, Masato Kusunoki, Stromal CXCR4 and CXCL12 Expression is Associated with Distant Recurrence and Poor Prognosis in Rectal Cancer After Chemoradiotherapy Annals of Surgical Oncology. ,vol. 17, pp. 2051- 2058 ,(2010) , 10.1245/S10434-010-0970-Y