microRNA expression is able to predict response to chemoradiotherapy in rectal cancer.

摘要: Although global microRNA (miRNA) expression patterns of several embryologic, physiological and oncogenic processes have been thoroughly studied, no studies are available on the role miRNAs in pre-operative chemoradiotherapy (CRT) rectal cancer. This study aimed to delineate pattern for prediction response CRT Rectal cancer patients (n=43), who underwent (40 Gy radiotherapy combined with S-1), were studied. RNA harvested from biopsy specimens prior was hybridized miRNA microarrays (821 genes). The evaluated by histopathological examination surgically resected specimens, Response Evaluation Criteria Solid Tumors (RECIST) downstaging. data microarray real-time reverse transcription-polymerase chain reaction (RT-PCR). Two (miR-142-3p, 223) an increased that correctly differentiated responders non-responders identified examination. One gene (miR-223) showed a higher, while 8 genes (miR-20b, miR-92a, let-7a*, miR-20a, miR-17*, miR-106a, miR-17 miR-20a*) lower compared nonresponders, regard RECIST. 3 (miR-223, miR-630 miR-126*) had higher non-responders, RT-PCR evaluation analysis detected miR-223 level non-responders. Consequently, candidate may be new biomarker useful when establishing tailor-made therapies