Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain.
作者： Yaoyu Pu , Lijia Chang , Youge Qu , Siming Wang , Kai Zhang
关键词: Dopamine transporter 、 Tyrosine hydroxylase 、 Dopamine 、 Pharmacology 、 Microbiome 、 Neurotoxicity 、 Substantia nigra 、 MPTP 、 Dopaminergic 、 Biology
摘要: Although the brain-gut axis appears to play a role in pathogenesis of Parkinson's disease, precise mechanisms underlying actions gut microbiota this disease are unknown. This study was undertaken investigate whether antibiotic-induced microbiome depletion affects dopaminergic neurotoxicity mouse brain after administration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP significantly decreased dopamine transporter (DAT) immunoreactivity striatum and tyrosine hydroxylase (TH) substantia nigra water-treated mice. However, did not decrease DAT or TH brains mice treated with an antibiotic cocktail. Furthermore, treatment diversity altered composition host at genus species levels. Interestingly, also antibiotic-treated These findings suggest that might protect against MPTP-induced via axis.
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