Genetic influences on motion sickness susceptibility in adult women: a classical twin study.

摘要: Background: Motion sickness is a common and potentially debilitating condition that characteristically occurs in situations of conflicting sensory input. While the precise stimuli give rise to this trait are increasingly well characterized, underlying determinants individual susceptibility motion remain unclear. This study uses classical twin design assess influence genetic environmental factors. Methods: A postal survey was conducted an age-matched sample 3652 monozygotic (MZ) dizygotic (DZ) adult female twins selected from TwinsUK Registry. Study participants were asked complete items validated questionnaire relating their lifetime sickness. The relative contribution factors assessed using variance components analysis. Results: response rate 78%. Approximately 40% respondents reported at least moderate pattern responses among indicated significant with heritability for factor score estimated as 57% (95% CI: 51%, 63%). recalled its highest childhood (70% [59%, 80%]) declined through puberty early years. Discussion Conclusions: findings highlight importance determining individual's propensity should stimulate search specific genes.