Musk shrews selectively bred for motion sickness display increased anesthesia-induced vomiting

摘要: Susceptibility to motion sickness is a predictor of postoperative nausea and vomiting, studies in humans suggest that genetic factors determine sensitivity sickness. The aim the current study was if preclinical model could be selectively bred for motion-induced emesis assess potential relationship anesthesia-induced emesis. Musk shrews were tested using shaker plate (10min, 1Hz, 4cm lateral displacement). Animals rank ordered produce high low response strains. Shrews also with nicotine (5mg/kg, sc), copper sulfate (CuSO4; 120mg/kg, ig), isoflurane anesthesia (10min; 3%) measure responses panel emetic stimuli. High strain demonstrated significantly more episodes exposure compared animals F1 F2 generations. In animals, there no significant differences total or latency between strains after injection CuSO4 gavage. However, stimulated versus which suggests vestibular- inhalational Overall, these results indicate determinants common mechanism Future work may include mapping "emetic genes" develop novel therapies diagnostics patients risk vomiting.