An assay of drug-induced emesis in the squirrel monkey (Saimiri sciureus).

摘要: BACKGROUND Emesis has significant evolutionary value as a defense mechanism against ingested toxins; however, it is also one of the most common adverse symptoms associated with both disease and medical treatments disease. The development improved antiemetic pharmacotherapies been impeded by shortage animal models. METHODS present studies characterized responses squirrel monkey to pharmacologically diverse emetic drugs. Subjects were administered nicotine (0.032-0.56 mg/kg), lithium chloride (150-250 mg/kg), arecoline (0.01-0.32 mg/kg), or apomorphine (0.032-0.32 mg/kg) observed for emesis prodromal hypersalivation. RESULTS Nicotine rapidly produced Lithium longer time course without dose-dependent Arecoline hypersalivation but not emesis. Apomorphine failed produce CONCLUSIONS sensitive drug-induced variety pharmacological mechanisms well-positioned examine efficacy clinically important side effects candidate pharmacotherapies.