Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew

摘要: Background Gastric electrical stimulation (GES) is implicated as a potential therapy for difficult-to-treat nausea and vomiting; however, there lack of insight into the mechanisms responsible these effects. This study tested relationship between acute GES emesis in musk shrews, an established emetic model system. Methods Urethane-anesthetized shrews were used to record responses (monitoring intra-tracheal pressure esophageal contractions), respiration rate, heart rate variability, blood pressure, gastrointestinal electromyograms. We investigated effects pulse duration (0.3, 1, 5, 10 ms), current amplitude (0.5, 2 mA), frequency (8, 15, 30, 60 Hz), electrode placement (antrum, body, fundus) on induced by gastric stretch, using balloon. Key Results There four outcomes: (i) did not modify stretch-induced emesis; (ii) produced emesis, depending parameters, but was less effective than stretch; (iii) other physiological changes closely associated with could be related sub-threshold activation system, including suppression breathing rise pressure; (iv) control experiment showed that 8-OH-DPAT, reported 5-HT1A receptor agonist acts centrally antiemetic, blocked emesis. Conclusions Inferences These results do support antiemetic effect distension-induced within range conditions tested, further evaluation should focus broader stimuli parameters.