Phosphorylation of STAT3 correlates with HER2 status, but not with survival in pancreatic ductal adenocarcinoma

摘要: Activation of signal-transcriptional factor signal transducer and activator transcription 3 (STAT3) is associated with more aggressive behaviour in a variety human malignancies. As selective STAT3 inhibitors exist, this protein might represent novel therapeutic target. Although seems to play an important role progression pancreatic ductal carcinoma (PDAC), only few data on subject exist. The aim our study was the investigation activation its correlation possible regulator HER2. Expression tyrosine-705 phosphorylated (pSTAT3) determined immunohistochemically 79 PDACs. HER2 status assessed by immunohistochemistry double colour silver situ hybridization available from previous study. PSTAT3 expression seen 33 (41.8%) patients. Six patients were scored as positive having strong pSTAT3 (p = 0.004, Fisher's exact test). No association patients' age, tumour staging grading, perineural invasion cells or survival time seen. frequently expressed PDAC. Nevertheless, immediate clinical relevance be low. However, further research needs determine whether PDAC predictive for response targeting therapies.