A Comparison of the Hydrochloride and Carbon Dioxide Salts of Lidocaine and Prilocaine in Epidural Analgesia

作者: Philip R. Bromage

DOI: 10.1111/J.1399-6576.1965.TB00523.X

关键词: PrilocaineHydrochlorideEpidural blockadeMotor blockadeBlockadePharmacologyAnalgesicMedicineCarbon dioxideLidocaineAnesthesia

摘要: SUMMARY Lumbar epidural blockade has been used in a series of 659 patients to compare the analgesic properties lidocaine and prilocaine. Solutions both compounds were compared as hydrochloride salts 2% 3% concentration with without adrenaline 1:200,000. Solutions base, made soluble by equilibration carbon dioxide at pC02 700 mm Hg also concentrations 1.75% for 1.71% prilocaine. Comparisons based on measurements latency, spread analgesia, intensity motor duration analgesia. The quality all test solutions was increased addition 1:200,000 adrenaline. Prilocaine slow latency lidocaine, but plain solution its is longer than that lidocaine. The have no practical advantage over die blockade. Analgesia resulting from C02-base superior every respect produced equivalent salts.

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