Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor

作者: R. Gundersen , J. Barrett

DOI: 10.1126/SCIENCE.493992

关键词: DorsumGanglionTurn (biochemistry)EndocrinologyChemotaxisTissue cultureInternal medicineCell biologyBeta (finance)Growth factorNerve growth factorBiology

摘要: Micropipettes containing 2 to 50 biological units of beta growth factor (NGF) were placed near growing axons chick dorsal-root ganglion neurons in tissue culture. The turned and grew toward the NGF source within 21 minutes. This turning response elevated concentrations appears represent chemotactic guidance rather than a general enhancement rate.

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