Oncologist's/haematologist's view on the roles of pathologists for molecular targeted cancer therapy

摘要: In the past two decades there has been a tremendous increase in understanding of molecular basis human malignancies. variety neoplasms, specific markers became part disease classifications and are now routinely used to define entities. Molecular analyses discriminate prognostic groups, guide differential treatment strategies identify targets for defined cancer therapy. A battery new drugs developed specifically inhibit oncogenic pathways. For an increasing number solid haematological malignancies, availability targeted fundamentally changed algorithms. However, diagnostic, therapeutic impact selected is still limited many cases. After all, success therapy clearly determined by significance structure biology ability malignant cell evade inhibition.