Regulatory dendritic cells for immunotherapy in immunologic diseases.

摘要: We recognize well the abilities of dendritic cells to activate effector T cell responses an array antigens and we think these in this context as pre-eminent antigen presenting cells, but are also critical induction immunologic tolerance. Herein review our knowledge around different kinds tolerogenic or regulatory that present can be induced experimental settings humans, how they operate disease which effective, from allergic autoimmune diseases transplant Central messages arise cumulative studies clearly indicate agent(s) used induce phenotype status at time influence not only cell, turn mobilize. For example, while many, if most, types lead CD4+ naive adopt a CD25+Foxp3+ Treg phenotype, exposure Langerhan’s dermal vitamin D leads one case downstream responses, other Foxp3- type 1 (Tr1) responses. Similarly, human immature versus semi-mature IL-10 distinct outcomes. Thus, it should possible shape immunotherapy approaches for selective tolerance simultaneously multiple This may prove important option target anatomic compartments with divergent pathologies clinic. Finally, provide overview use potential clinically, highlighting their tools settings.