Functional study of immature dendritic cells co-transfected with IL-10 and TGF-beta 1 genes in vitro
作者： Lihong Chen , Minglian Qiu , Wubing He , Aimin Huang , Jingfeng Liu
DOI: 10.1007/S11033-012-1468-4
关键词: T cell 、 MHC class II 、 Immune tolerance 、 Cell biology 、 TGF beta 1 、 Biology 、 Immune system 、 CD86 、 Interleukin 10 、 CD80
摘要: Dendritic cells (DC) have important functions in T cell immunity and tolerance. Previous studies suggest that immature dendritic (imDCs) might be involved the induction of peripheral While interleukin-10 (IL-10) at different levels immune response, transforming growth factor-beta 1 (TGF-beta 1) is considered to a key factor In this study, we investigated effects DC (imDC) co-transfected with IL-10 TGF-beta genes (IL-10-TGF-beta 1-imDC) on inducing Moreover, compared IL-10-TGF-beta 1-imDC transfected imDC (IL-10-imDC) 1-transfected 1-imDC), respectively. resulted down-regulation MHC class II, CD80 CD86. could induce hyporesponsiveness, was reluctant proliferate. more effective than IL-10-imDC 1-imDC, summary, co-expression affected imDCs enhanced their tolerogenicity. It promising therapy for donor-specific tolerance after organ transplantation.
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