The distribution of HLA-A,B, DR antigens in Chinese myasthenia gravis.
作者： P. Thajeb , C-Y. Chee , C-C. Huang
DOI: 10.1111/J.1399-0039.1987.TB01586.X
关键词: Immunogenetics 、 Autoimmune disease 、 Lymphocyte 、 Immunopathology 、 Medicine 、 Myasthenia gravis 、 HLA-A 、 Immunology 、 Antigen 、 Human leukocyte antigen
摘要: The association of HLA antigens with Myasthenia Gravis (MG) in many different races is well known. In this study, HLA-A, B and DR were typed on 65 Chinese MG 232 controls for 61 antigens. A2 DRw9 increased significantly patients (p less than 0.025 p 0.05 respectively). DR2 DR4 had the opposite influence (both 0.005). Several alleles shown to have relatively high values P D/A relative risk but low A/D E.F, which suggests marker heterogeneity MG. Comparisons clinically types MG, variations age onset thymic pathology did not show any statistically significant difference distributions. clinical implications discussed.
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