Kinesins and cancer

作者: Oliver Rath , Frank Kozielski

DOI: 10.1038/NRC3310

关键词: CancerKinesinKIF4AKIF15MicrotubuleCell divisionBiologyCell biologyMitosisMolecular motor

摘要: Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins involved mitosis have emerged as potential targets for cancer drug development. Several compounds inhibit two mitotic (EG5 (also known KIF11) and centromere-associated protein E (CENPE)) entered Phase I II clinical trials either monotherapies combination with other drugs. Additional currently being validated targets, raising possibility range kinesin-based may expand future.

参考文章(212)
N. Tokai, A. Fujimoto-Nishiyama, Y. Toyoshima, S. Yonemura, S. Tsukita, J. Inoue, T. Yamamota, Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. The EMBO Journal. ,vol. 15, pp. 457- 467 ,(1996) , 10.1002/J.1460-2075.1996.TB00378.X
Goldie Jh, Coldman Aj, A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer treatment reports. ,vol. 63, pp. 1727- 1734 ,(1979)
Daisy Wing-Sze Wong, Elaine Lai-Han Leung, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, Joseph Siu-Kie Au, Lap-Ping Chung, Maria Pik Wong, A novel KIF5B-ALK variant in nonsmall cell lung cancer. Cancer. ,vol. 117, pp. 2709- 2718 ,(2011) , 10.1002/CNCR.25843
David J. Sharp, Gregory C. Rogers, Jonathan M. Scholey, Microtubule motors in mitosis Nature. ,vol. 407, pp. 41- 47 ,(2000) , 10.1038/35024000
Siro Simizu, Hiroyuki Osada, Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines Nature Cell Biology. ,vol. 2, pp. 852- 854 ,(2000) , 10.1038/35041102
T. J. Yen, D. A. Compton, D. Wise, R. P. Zinkowski, B. R. Brinkley, W. C. Earnshaw, D. W. Cleveland, CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. The EMBO Journal. ,vol. 10, pp. 1245- 1254 ,(1991) , 10.1002/J.1460-2075.1991.TB08066.X
Satoko Aoki, Keisuke Ohta, Takayuki Yamazaki, Fumio Sugawara, Kengo Sakaguchi, Mammalian mitotic centromere‐associated kinesin (MCAK) FEBS Journal. ,vol. 272, pp. 2132- 2140 ,(2005) , 10.1111/J.1742-4658.2005.04600.X
S. F. Jones, E. R. Plummer, H. A. Burris, A. R. Razak, A. A. Meluch, C. J. Bowen, D. H. Williams, J. P. Hodge, M. M. Dar, A. H. Calvert, Phase I study of ispinesib in combination with carboplatin in patients with advanced solid tumors. Journal of Clinical Oncology. ,vol. 24, pp. 2027- 2027 ,(2006) , 10.1200/JCO.2006.24.18_SUPPL.2027
Miho Ohsugi, Kenjiro Adachi, Reiko Horai, Shigeru Kakuta, Katsuko Sudo, Hayato Kotaki, Noriko Tokai-Nishizumi, Hiroshi Sagara, Yoichiro Iwakura, Tadashi Yamamoto, Kid-Mediated Chromosome Compaction Ensures Proper Nuclear Envelope Formation Cell. ,vol. 132, pp. 771- 782 ,(2008) , 10.1016/J.CELL.2008.01.029
Guikai Wu, Longen Zhou, Lily Khidr, Xuning Emily Guo, Wankee Kim, Young Mi Lee, Tatiana Krasieva, Phang-Lang Chen, None, A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle. ,vol. 7, pp. 2013- 2020 ,(2008) , 10.4161/CC.7.13.6130