Vertebral Aspergillus Osteomyelitis and Acute Diskitis in Patients With Chronic Obstructive Pulmonary Disease

摘要: Aspergillus osteomyelitis of the spine with acute diskitis has been well documented in immunocompromised hosts but is rare immunocompetent patients. Predisposing factors to infection are prolonged neutropenia, hematologic malignancies, chemotherapy, history prior spinal trauma or surgery, allograft transplantation, any condition requiring use long-term immunosuppressive agents systemic corticosteroids. Patients chronic obstructive pulmonary disease (COPD) treated corticosteroids for either management frequent exacerbations at potential risk such infections. severe COPD primarily inhaled considered immunocompetent. This report describes 2 cases apparently patients who, aside from brief courses corticosteroids, were using corticosteroid therapy. One patient was intravenous amphotericin B alone, whereas other received and underwent surgical debridement. Both have done symptom free 6-month follow-up.