Increase of Meningitis Risk in Stroke Patients in Taiwan.

摘要: Background and purpose: The blood-brain barrier (BBB) not only provides a physical obstruction, but also recruits activates neutrophils in cases of infection. Hemorrhagic or ischemic stroke reportedly induces the disruption BBB. However, few studies have reported correlation between incidence meningitis patients with history stroke. present study tested hypothesis that may be more vulnerable to meningitis. Methods: Stroke age-matched comparison (n = 29,436 87,951, respectively) cohorts were recruited from Taiwan National Health Insurance (TNHI) database (2000 2011). Correlations two evaluated by Cox proportional hazard regression model, Kaplan-Meier curve, log-rank tests. Results: was higher cohort compared (hazard ratio [HR], 2.89; 95% confidence interval [CI], 2.23-3.74, p < 0.001). After adjusting for age, sex, comorbidities, estimated 2.55-fold than (CI, 1.94-3.37, Notably, who had experienced hemorrhagic rate those stroke, except older 75 years age (incidence rates hemorrhagic/ischemic patients, 3.14/1.48 younger 45 1.52/0.41 45-64-years group, 1.15/0.90 65-74-years 0.74/0.93 age). Moreover, undergone head surgery highest risk (adjusted HR, 8.66; CI, 5.55-13.5, 0.001) followed 2.11; 1.57-2.82, Conclusions: Our results indicated risks Compromised BBB integrity lead increased vulnerability infectious pathogens. In summary, our provided new evidence clinical relationship findings suggest need precautions prevent patients.