Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts: A Finite Element Investigation
作者： Martin Weidling , Silke Besdo , Tobias Schilling , Michael Bauer , Thomas Hassel
DOI: 10.1007/978-3-319-10981-7_6
关键词: Scaffold 、 Magnesium alloy 、 Implant 、 Ultimate tensile strength 、 Metallurgy 、 Design modification 、 Stress reduction 、 Finite element method 、 Biomedical engineering 、 Myocardial tissue 、 Materials science
摘要: Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these and gradually lose their function as graft develops its are a possible solution. We developing magnesium alloy scaffolds this purpose. The finite element method was used to perform simulations wherein deformed according heart movement. This allows us identify highly stressed regions within implant need design changes. Preformed were determined have significantly lower stresses in comparison flat ones. tensile triangles suggests shape changes notable stress reduction. Furthermore, new scaffold shapes developed simulated. Two them recommended further examinations through vitro vivo tests. A completely alternative concept also proposed.
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