Geometric adaption of biodegradable magnesium alloy scaffolds to stabilise biological myocardial grafts. Part I

摘要: Synthetic patch materials currently in use have major limitations, such as high susceptibility to infections and lack of contractility. Biological grafts are a novel approach overcome these but do not always offer sufficient mechanical durability early stages after implantation. Therefore, stabilising structure based on resorbable magnesium alloys could support the biological graft until its physiologic remodelling. To prevent breakage vivo due stress non-determined forming, scaffolds should be preformed according geometry targeted myocardial region. Thus, left ventricular 28 patients was assessed via standard cardiac magnetic resonance imaging (MRI). The resulting data served basis for finite element simulation (FEM). Calculated stresses strains flat were evaluated. Afterwards, structures manufactured by abrasive waterjet cutting MRI data. Finally, compared an vitro test rig. FEM predicted higher scaffolds, which proven test. In conclusion, provide extended will facilitate more widespread regenerative surgical reconstruction.