Relationship between histologic response and the degree of tumor shrinkage after chemoradiotherapy in patients with locally advanced rectal cancer.

摘要: Background Preoperative chemoradiotherapy (CRT) significantly decreases local recurrence in advanced rectal cancer. We studied whether the degree of tumor shrinkage can be used as a predictor histologic response. Methods The subjects were 114 patients with locally cancer who underwent total mesorectal excision after receiving radiotherapy combined uracil/tegafur (UFT) or S-1. based on barium enema examination and magnetic resonance imaging (MRI) assessed before CRT immediately surgery. Results A complete response (ypCR), marked regression, T N downstaging associated higher tumor-shrinkage rates (P<0.01, P<0.01, respectively) well MRI P=0.01, respectively). On multivariate analysis, ypCR regression related only to (P<0.01 respectively), not MRI. Conclusions is closely final Two-dimensionally evaluated are adequate for prediction J. Surg. Oncol 2014; 109:659-664. (c) 2013 Wiley Periodicals, Inc.