Vernonia polyanthes as a new source of antiulcer drugs.
作者： Victor Barbastefano , Maira Cola , Anderson Luiz-Ferreira , Elisângela Farias-Silva , Clélia A. Hiruma-Lima
DOI: 10.1016/J.FITOTE.2007.07.003
关键词: Lansoprazole 、 Gastric mucosa 、 Phytotherapy 、 Pharmacology 、 Cimetidine 、 Anti-ulcer Agent 、 Pharmacognosy 、 Antiulcer drug 、 Medicine 、 Mechanism of action
摘要: Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration VPME (250 mg/kg) VPCL (50 significantly inhibited gastric mucosa damage (64% 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced damage, their gastroprotective effects have decreased. Since extract resulted to be more effective than we focused our efforts over action mechanism action.
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