Hyperplasia, Hyperkeratosis and Benign-Tumor Production in Transgenic Mice by a Targeted V-Fos Oncogene Suggest a Role for Fos in Epidermal Differentiation and Neoplasia

摘要: A vector, derived from the human K1 keratin gene, has been employed to target v-fos expression exclusively in epidermis of transgenic mice. Adult mice expressors (3-4 months) displayed hyperplasia and hyperkeratosis, initially wounded (tagged) ears, which later became bilateral. This phenotype appeared at other epidermal sites, most notably axilla inguinal areas. indicates that a second promoting event, such as wounding or friction, is required elicit these pathological changes. Highly keratotic benign ear lesions squamous papillomas after long latency sites phenotypic epidermis. These data suggest may be interfering with c-fos function normal keratinocyte differentiation, but by itself insufficient overt lesions.