Isolation and utilization of epidermal keratinocytes for oncogene research.
作者： Andrzej A. Dlugosz , Adam B. Glick , Tamar Tennenbaum , Wendy C. Weinberg , Stuart H. Yuspa
DOI: 10.1016/0076-6879(95)54003-2
关键词:
摘要: Publisher Summary This chapter focuses on the isolation and utilization of epidermal keratinocytes for oncogene research. Keratinocytes have been widely used as target cells testing activity oncogenes in epithelial neoplasia. Many experimental studies utilized cultured mouse skin keratinocytes, where vitro results can be analyzed context a substantial experience carcinogen-induced tumors. Studies also revealed biological consequences expressing v-los derivatives, neu, mutant p53, transforming growth factor α (TGF-α ). These focused participation mediators premalignant progression malignant conversion. The effects oncogenic DNA viruses tested particular emphasis has directed toward expression simian virus 40 (SV40) specific subtypes human or bovine papilloma (HPV, BPV) their sequences. provides details techniques employed influence several general conclusions from are presented.
elsevier.com
sci-hub.se 参考文章(95)
D. S. Bundman, D. R. Roop, J. A. Rothnagel, C. C. Orengo, M. A. Longley, T. A. Gagne, M. I. Quintanilla, C. Fisher, D. A. Greenhalgh, Xiao-Jing Wang, Hyperplasia, Hyperkeratosis and Benign-Tumor Production in Transgenic Mice by a Targeted V-Fos Oncogene Suggest a Role for Fos in Epidermal Differentiation and Neoplasia Oncogene. ,vol. 8, pp. 2145- 2157 ,(1993)
Lowell A. Goldsmith, Physiology, biochemistry, and molecular biology of the skin Oxford University Press. ,(1991)
Erich Hecker, W. Tilgen, F. Marks, E. G. Jung, Skin Carcinogenesis in Man and in Experimental Models ,(1993)
Federico Bertolero, M.Edward Kaighn, Matthew A. Gonda, Umberto Saffiotti, Mouse epidermal keratinocytes Experimental Cell Research. ,vol. 155, pp. 64- 80 ,(1984) , 10.1016/0014-4827(84)90768-7
Sheibani N, Allen-Hoffmann Bl, Rhim Js, Malignant human papillomavirus type 16-transformed human keratinocytes exhibit altered expression of extracellular matrix glycoproteins. Cancer Research. ,vol. 51, pp. 5967- 5975 ,(1991)
J R Bates, R H Gray, T Shimada, J D Rossen, N H Colburn, W F Bruegge, W H Kelsey, Correlation of Anchorage-independent Growth with Tumorigenicity of Chemically Transformed Mouse Epidermal Cells Cancer Research. ,vol. 38, pp. 624- 634 ,(1978)
Vincent F. Vellucci, Zhao-ling Zhou, Michael Reiss, Mutant p53 Tumor Suppressor Gene Causes Resistance to Transforming Growth Factor β1 in Murine Keratinocytes Cancer Research. ,vol. 53, pp. 899- 904 ,(1993)
J B Hudson, M A Bedell, D J McCance, L A Laiminis, Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18. Journal of Virology. ,vol. 64, pp. 519- 526 ,(1990) , 10.1128/JVI.64.2.519-526.1990
Henry Hennings, James E. Strickland, Stuart H. Yuspa, David A. Greenhalgh, Aneta Koceva-Chyla, Clara Restrepo, Michael Balaschak, Development of Murine Epidermal Cell Lines Which Contain an Activated rasHa Oncogene and Form Papillomas in Skin Grafts on Athymic Nude Mouse Hosts Cancer Research. ,vol. 48, pp. 165- 169 ,(1988)
Richard L. Eckert, Chapla Agarwal, Immortalization of human keratinocytes by simian virus 40 large T-antigen alters keratin gene response to retinoids. Cancer Research. ,vol. 50, pp. 5947- 5953 ,(1990)