5-Fluorouracil-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(lactide-co-glycolide) polymers: characterization and drug release.
作者： M. D. Blanco , R. L. Sastre , C. Teijón , R. Olmo , J. M. Teijón
DOI: 10.1080/02652040500161990
关键词: Dosage form 、 Molar mass distribution 、 Microparticle 、 Chemical engineering 、 Controlled release 、 Materials science 、 Polymer 、 Spray drying 、 Copolymer 、 PLGA 、 Organic chemistry
摘要: 5-Fluorouracil (5-FU), a hydrosoluble anti-neoplastic drug, was encapsulated in microspheres of poly(D,L-lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) polymers using the spray-drying technique, order to obtain small size with significant drug entrapment efficiency. Drug-loaded included between 47 ± 11 67 ± 12 µg 5-FU mg−1 percentage efficiency 52 ± 12 74 ± 13. Microspheres were (average diameter: 0.9 ± 0.4–1.4 ± 0.8 µm without drug; 1.1 ± 0.5–1.7 ± 0.9 µm 5-FU-loaded microspheres) their surface smooth slightly porous, some hollows or deformations observed prepared from larger Tg. A fractionation process raw polymer during formation as an increase average molecular weight also Tg microspheres. The presence 5-FU did not modify values Sign...
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