Neuropsychology and clinical neuroscience of persistent post-concussive syndrome.

摘要: On the mild end of acquired brain injury spectrum, terms concussion and traumatic (mTBI) have been used interchangeably, where persistent post-concussive syndrome (PPCS) has a label given when symptoms persist for more than three months post-concussion. Whereas brief history research is overviewed, focus this review on current status PPCS as clinical entity from perspective recent advances in biomechanical modeling human animal studies, particularly directed at better understanding neuropathology associated with concussion. These studies implicate common regions injury, including upper brainstem, base frontal lobe, hypothalamic-pituitary axis, medial temporal fornix, corpus callosum. Limitations neuropsychological techniques assessment memory executive function are explored recommendations improved designs offered, that may enhance study long-term sequelae (JINS, 2008, 14, 1–22.)