The Ste20 Kinase MST4 Plays a Role in Prostate Cancer Progression
作者： Victoria Sung , Isabelle Lee , Wen Luo , Mikhail Gishizky , Dapeng Qian
DOI:
关键词: Prostate cancer 、 Epidermal growth factor receptor 、 Carcinogenesis 、 Signal transduction 、 A431 cells 、 Tumor progression 、 Biology 、 Cancer research 、 Kinase activity 、 LNCaP
摘要: MST4, a member of the Sterile 20 serine/threonine kinase family, was found to be expressed in prostate carcinoma tumor samples and cell lines. In addition, expression levels appeared correlate with tumorigenicity androgen receptor status cells. Ectopic wild-type kinase-inactive MST4 used alter cellular activity three widely studied human lines: LNCaP, DU 145, PC-3. Overexpression induced anchorage-independent growth LNCaP line, increased both vitro proliferation vivo tumorigenesis 145 line. On other hand, form reverted phenotype highly tumorigenic behavior PC-3 stimulated significantly by epidermal factor ligands, which are known promote cancer Together, our studies suggest potential role for signal transduction pathways involved progression.
aacrjournals.org参考文章(45)
M. Lieberherr, B. Grosse, Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. Journal of Biological Chemistry. ,vol. 269, pp. 7217- 7223 ,(1994) , 10.1016/S0021-9258(17)37270-8
Noah Craft, Yuriy Shostak, Michael Carey, Charles L. Sawyers, A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nature Medicine. ,vol. 5, pp. 280- 285 ,(1999) , 10.1038/6495
Christian Radmayr, Alfred Hobisch, Jan Trapman, Georg Bartsch, Anton Hittmair, Helmut Klocker, Zoran Culig, Marcus V. Cronauer, Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor Cancer Research. ,vol. 54, pp. 5474- 5478 ,(1994)
J C den Hartigh, P M van Bergen en Henegouwen, A J Verkleij, J Boonstra, The EGF receptor is an actin-binding protein. Journal of Cell Biology. ,vol. 119, pp. 349- 355 ,(1992) , 10.1083/JCB.119.2.349
David T Price, GREGORY DELLA ROCCA, ChuanHai Guo, Michael S Ballo, Debra A Schwinn, Louis M Luttrell, ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN HUMAN PROSTATE CANCER The Journal of Urology. ,vol. 162, pp. 1537- 1542 ,(1999) , 10.1016/S0022-5347(05)68354-1
Donna M. Peehl, Cellular biology of prostatic growth factors. The Prostate. ,vol. 29, pp. 74- 78 ,(1996) , 10.1002/(SICI)1097-0045(1996)6+<74::AID-PROS14>3.0.CO;2-O
Timothy Turnert, Philip Chen, Lyndon J. Goodly, Alan NWells, EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells Clinical & Experimental Metastasis. ,vol. 14, pp. 409- 418 ,(1996) , 10.1007/BF00123400
S. Yeh, H.-K. Lin, H.-Y. Kang, T. H. Thin, M.-F. Lin, C. Chang, From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 5458- 5463 ,(1999) , 10.1073/PNAS.96.10.5458
Eric J. Small, Advances in prostate cancer. Current Opinion in Oncology. ,vol. 11, pp. 226- 235 ,(1999) , 10.1097/00001622-199905000-00016
Jei-Liang Lin, Hua-Chien Chen, Hsin-I Fang, Dan Robinson, Hsing-Jien Kung, Hsiu-Ming Shih, MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. ,vol. 20, pp. 6559- 6569 ,(2001) , 10.1038/SJ.ONC.1204818