A Predictive Nomogram for Recurrence of Carcinoma of the Major Salivary Glands

摘要: Importance This nomogram quantifies the risk of recurrence in patients with carcinoma major salivary glands. It may facilitate patient counseling on prognosis and help guide management posttreatment surveillance these patients. Objectives To identify factors predictive after primary surgical treatment glands create a that could be used to predict an individual patient. Design Retrospective case series. Setting Single institution tertiary care cancer center. Patients After institutional review board approval, 301 previously untreated malignant gland tumors treated at our between years 1985 2009 were identified. Among patients, median age was 62 (range, 9-89) 156 (52%) male. Patient, tumor, characteristics recorded from retrospective analysis medical charts. Main Outcomes Measures Overall mortality calculated using Kaplan-Meier method. Disease-specific estimated cumulative incidence rate. Factors identified univariate analysis. A Cox proportional hazard model select predictors for nomogram. Results With follow-up 43 1-264) months, 5-year overall mortality, disease-specific rate 30%, 28%, 33%, respectively. There 70 recurrences (18 local, 12 regional, 56 distant). The 5 variables most age, grade, vascular perineural invasion, nodal metastasis. These selected generate nomogram, which had high concordance index 0.85. Conclusions Relevance We introduce clinically useful carcinomas gland. By quantifying patient, this would enable clinician give more accurate prognostic information resulting better counseling.