Development and internal validation of a prognostic model to predict recurrence free survival in patients with adult granulosa cell tumors of the ovary.

摘要: Abstract Objective Models to predict the probability of recurrence free survival exist for various types malignancies, but a model in individuals with an adult granulosa cell tumor (GCT) ovary is lacking. We aimed develop and internally validate such prognostic model. Methods performed multicenter retrospective cohort study patients GCT. Demographic, clinical pathological information were considered as potential predictors. Univariable multivariable analyses using Cox proportional hazards Using backward stepwise selection we identified combination predictors that best predicted survival. Discrimination (c-statistic) calibration used assess performance. The was validated bootstrapping techniques correct overfitting. To increase applicability developed nomogram allow individual prediction Results 127 GCT (median follow-up time 131months (IQR 70-215)). Recurrence occurred 81 out (64%). following four variables jointly survival; stage, Body Mass Index (BMI), diameter mitotic index. had c-statistic 0.73 (95% CI 0.66–0.80) showed accurate calibration. Conclusions can be accurately by BMI, introduced could facilitate counseling may help guide caregivers joint decisions on post-treatment surveillance.