Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

摘要: The histopathologic features of adult granulosa cell tumors (AGCTs) are relatively nonspecific, resulting in misdiagnosis other cancers as AGCT, a problem that has not been well characterized. FOXL2 mutation testing was used to stratify 336 AGCTs from three European centers into categories: 1) mutant molecularly defined AGCT (MD-AGCT) (n = 256 336), 2) wild-type (n = 17 3) misdiagnosed tumor types (n = 63 336). All statistical tests were two-sided. overall and disease-specific survival the cases lower than MD-AGCTs (P < .001). accounted for 71.9% deaths within five years. In population-based cohort, MD-AGCT patients different age-matched, controls. Even though 35.2% all our study experienced relapse, is usually an indolent disease. historical, premolecular data underpinning clinical understanding likely skewed by inclusion cases, future management strategies should reflect potential surgical cure long even after relapse.