Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis
作者： Sui Xiong Cai , Han-Zhong Zhang , Songchun Jiang
DOI:
关键词: Cell biology 、 Caspase 、 Inducer 、 Biochemistry 、 Biology 、 Programmed cell death 、 Gambogic acid 、 Abnormal cell 、 Apoptosis
摘要: The present invention is directed to derivatives of gambogic acid and analogs thereof. Exemplary the include, among others, substituted in C10 C28 positions acid. also relates discovery that certain preferred compounds are activators caspases inducers apoptosis. Therefore, apoptosis this can be used induce cell death a variety clinical conditions which uncontrolled growth spread abnormal cells occurs.
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