Bax, a Proapoptotic Protein Forming Channels in Mitochondria
作者： Jean-Claude Martinou , Bruno Antonsson
DOI: 10.1007/978-1-59259-720-8_9
关键词: Membrane 、 Apoptosis 、 Cytosol 、 Membrane potential 、 Adenine nucleotide translocator 、 Chemistry 、 Ion channel 、 Inner mitochondrial membrane 、 Cell biology 、 Mitochondrion
摘要: Bax is a member of the Bcl-2 family proteins, with proapoptotic activity. In cells, protein found in cytosol and mitochondrial membrane. At least some cell types, translocation from to mitochondria has been detected during apoptosis. The contains hydrophobic C-terminal domain presumably involved membrane attachment. can form ion channels artificial lipid membranes: These be described as multiconductance, pH-sensitive, voltage-sensitive rather poor selectivity. Overexpression or addition recombinant isolated mitochondria, triggers loss potential release cytochrome-c, both early events
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