Latent activity of curcumin against leishmaniasis in vitro.
作者： Danish Saleheen , Syed Atif Ali , Khalid Ashfaq , Anwar Ali Siddiqui , Ajmal Agha
DOI: 10.1248/BPB.25.386
关键词: Microbiology 、 Leishmania major 、 Curcumin 、 Pentamidine 、 Biology 、 Leishmaniasis 、 Leishmania tropica 、 Leishmania 、 Leishmania infantum 、 Amastigote
摘要: In this study the anti-proliferative effect of curcumin (curcuma longa) that is active ingredient ground dried rhizome has been studied against three local and reference leishmanial strains, Leishmania major, tropica infantum (Pakistani isolate). Curcumin shown an average IC50 5.3 microM promastigotes various strains which much lower as compared with pentamidine one basic treatments leishmaniasis. The main draw back attributed to these assays performed on heterogeneity results those obtained intracellular amastigotes or in vivo effect. We also tested activity axenic amastigote like cells (AALC) L. major strain (MHOM/PK/88/DESTO). proves be far more potent then AALC further strengthens fact about its leishmaniacidal activity.
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