New therapeutic targets for cancer bone metastasis

摘要: Bone metastases are dejected consequences of many types tumors including breast, prostate, lung, kidney, and thyroid cancers. This complicated process begins with the successful tumor cell epithelial–mesenchymal transition, escape from original site, penetration into circulation. The homing cells to bone depends on both tumor-intrinsic traits various molecules supplied by metastatic niche. colonization growth cancer in osseous environment, which awaken their dormancy form micro- macro-metastasis, involve an intricate interaction between circulating local osteoclasts, osteoblasts, adipocytes, macrophages. We discuss most recent advances identification new novel mechanisms during each step metastasis that may serve as promising therapeutic targets.