Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment
作者： D. B. Klug , C. Carter , E. Crouch , D. Roop , C. J. Conti
关键词: Immunology 、 Cellular differentiation 、 Thymocyte 、 Lineage (genetic) 、 Biology 、 Recombination-activating gene 、 Cell biology 、 FOXN1 、 TEC 、 IL-2 receptor 、 Transplantation
摘要: Thymocyte and thymic epithelial cell (TEC) development are interdependent processes. Although lineage relationships among progressively maturing thymocyte subsets have been characterized, the developmental TEC obscure. Because cells express distinct keratin (K) species as a function of differentiation stage proliferative status, we used K expression patterns to identify mouse determine their relationships. As expected, cortical medullary in normal thymus. However, detected two subsets, major K8+K5− subset minor K8+K5+ subset, which is highly represented at cortico-medullary junction. Both also present recombination activating gene 1 (RAG-1−/−) TCRβxδ−/− thymi T-cell blocked CD4−CD8−CD25+CD44− pre-T stage. In contrast, TECs predominate human CD3ɛ transgenic mice an earlier CD4−CD8−CD25−CD44+ Transplantation newborn under kidney capsule RAG-1−/− results emergence concomitant with appearance CD25+ thymocytes. Together, data suggest that proceeds from precursor process commitment.
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