A new synthetic route to polyaza-crown macrocycles through the per(N-formyl)polyaza-crowns
作者： Jerald S. Bradshaw , Krzysztof E. Krakowiak , Haoyun An , Reed M. Izatt
关键词: Medicinal chemistry 、 Chemistry 、 Polyamine 、 Formylation 、 Stereochemistry 、 Crown (botany) 、 Hydrolysis 、 Protecting group 、 Ring (chemistry)
摘要: Seven new per(N-formyl)polyaza-crown macrocycles 1-7 containing 14 to 21 ring members have been synthesized in yields of over 40% via the cyclization reaction appropriate per(N-formyl)polyamine 11-13 with ditosylate, dibromide or diiodide. Three per(N-formyl) 5-7 were hydrolyzed under acidic conditions give unsubstituted polyaza 8-10 77%.
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