Role of N-acetylcysteine in prevention of contrast-induced nephropathy after cardiovascular procedures: A meta-analysis

摘要: Background: Contrast-induced nephropathy is one of the common causes acute renal insufficiency after cardiovascular procedures. Hypothesis: The objective this paper was to analyze published data on usefulness N-acetylcysteine in prevention contrast-induced these procedures. Methods: Trials were selected if they prospective, randomized, controlled, had patients with impaired function, used low-osmolality, nonionic contrast media intra-arterially, administered a total four doses N-acetyl-cysteine addition intravenous saline hydration, and as their primary outcome. defined an increase serum creatinine concentration by > 0.5 mg/dl or 25% above baseline at within 48 h post procedure. Meta-analysis performed using Fisher's Combined Test measure effect size. magnitude estimated random-effects models. Homogeneity evaluated chi-square test homogeneity standard Q statistic. Reporting bias explored Rosenthal method. Results: significant p < 0.005 favor N-acetylcysteine. size reduce 20%. There 62% relative risk reduction fixed-effects model, 70% model. In addition, we found that 27 unpublished trials showing no effects would exist overturn combined significance five our meta-analysis. Conclusion: Oral administration hydration has beneficial procedures function.