Liver expression of Nrf2-related genes in different liver diseases.
作者： Ming-Liang Cheng , Yuan-Fu Lu , Hong Chen , Zhong-Yang Shen , Jie Liu
DOI: 10.1016/S1499-3872(15)60425-8
关键词: Liver disease 、 Endocrinology 、 Gene expression 、 Medicine 、 Hepatocellular carcinoma 、 GCLM 、 Hepatitis B 、 Alcoholic liver disease 、 Cirrhosis 、 Pathology 、 GCLC 、 Internal medicine
摘要: Background The KEAP1-Nrf2 antioxidant signaling pathway is important in protecting liver from various insults. However, little known about the expression of Nrf2-related genes human different diseases. Methods This study utilized normal donor tissues (n=35), samples patients with hepatocellular carcinoma (HCC, n=24), HBV-related cirrhosis (n=27), alcoholic (n=5) and end-stage disease (n=13). All were Oriental Liver Transplant Center, Beijing, China. expressions Nrf2 genes, including its negative regulator Kelch-like ECH-associated protein 1 (KEAP1), targeted gene NAD(P)H-quinone oxidoreductase (NQO1), glutamate-cysteine ligase catalytic subunit (GCLC) modified (GCLM), heme oxygenase (HO-1) peroxiredoxin-1 (PRDX1) evaluated. Results was decreased HCC, increased disease. KEAP1 all samples. most notable finding NQO1 HCC (18-fold), (6-fold), (5-fold) (3-fold). Peri-HCC also had 4-fold higher mRNA as compared to livers. GCLC levels lower only livers peri-HCC tissues. GCLM HO-1 except for HCC. PRDX1 Conclusion are aberrantly expressed diseases increase finding, especially
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