Retroviral Reverse Transcriptases: Error Frequencies and Mutagenesis

摘要: For most organisms the fidelity of genomic replication is an exceptionally accurate process. This accuracy must be high enough to guarantee that nucleotide sequence parent transmitted subsequent generations with few if any errors. Infrequent errors are required, however, produce mutations drive evolution species through selection. Survival within a hostile environment governed by selection variants, generating new best able survive in surrounds them. might favored populations containing wide spectrum pre-existing mutants provide diverse repertoire for