Quantitative ultrasonic assessment for detecting microscopic cartilage damage in osteoarthritis

摘要: Osteoarthritis (OA) is one of the most prevalent chronic conditions. The histological cartilage changes in OA include surface erosion and irregularities, deep fissures, alterations staining matrix. reversibility these chondral still under debate. It expected that clinical basic science studies will provide clinician with new scientific information about natural history optimal treatment at an early stage. However, a reliable method for detecting microscopic has not yet been established. We have developed novel system evaluating articular cartilage, which acoustic properties are measured by introducing ultrasonic probe into knee joint arthroscopy. purpose this study was to assess damage using evaluation on collagenase-treated vivo vitro. Ultrasonic echoes from were converted wavelet map transformation. On map, maximum magnitude echo duration selected as quantitative indices. Using indices, examined elucidate relationships analysis biochemical, biomechanical analyses. In vitro study, decreased collagenase digestion increased. Correlations observed between proteoglycan content biochemical findings, aggregate modulus findings. From matrix layer depth 500 μm closely related magnitude. increasing injection. There significant correlation modulus. therefore successfully detected degenerated use collagen-induced OA.