Field trial for assessment of avian influenza vaccination effectiveness in Indonesia.
作者： A. BOUMA , A. TEGUH MULJONO , A. JATIKUSUMAH , A.J. NELL , S. MUDJIARTININGSIH
关键词: Titer 、 Flock 、 Vaccination 、 Virology 、 H5N1 vaccine 、 Influenza A virus subtype H5N1 、 Antibody 、 Outbreak 、 Veterinary medicine 、 Diva 、 Medicine
摘要: The aim of this field study was to determine the efficacy vaccination against highly pathogenic avian influenza (HPAI) virus strain H5N1 in Indonesia. A limited, prototype clinical trial performed using a standardised treatment group, which poultry flocks were vaccinated at least twice with selected vaccine, and control group comprising treated non-standardised procedures chosen by farmer. Each consisted six either layers or native chickens. Haemagglutination inhibition (HI) antibody levels determined regular serum sampling, outbreak surveillance relied on non-AI-vaccinated sentinel birds. After three vaccinations high titres produced percentage an HI titre > 40 approximately 90%. Although no conclusions can be drawn regarding reduction transmission, demonstrated that 11 farms remained free from AI during observation period, programme based differentiating infected animals (DIVA) implemented.
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